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. 2022 Mar 18;12:4661. doi: 10.1038/s41598-022-08815-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map on circulating serum markers in SSc, diffuse SSc subset and SSc specific autoantibodies (Color print necessary). Mean serum marker values of the SSc group compared to healthy controls and reported as color ratios. Subsets are compared within the SSc cohort; dcSSc is compared to lcSSc, while ACA and ATA positive subsets are compared to ACA and ATA negative subsets, respectively. Colors reflect upregulated serum marker ratios, white squares indicate downregulation, and black squares indicate no significant alteration. ACA anti-centromere antibodies, ATA anti-topoisomerase-I antibodies, CCL C–C motif ligand, CD cluster of differentiation, CXCL C-X-C motif ligand, dcSSc diffuse cutaneous systemic sclerosis, DKK1 Dickkopf-related protein 1, HGF hepatocyte growth factor, IL interleukin, PLGF placental growth factor, SSc systemic sclerosis, TRAIL tumor necrosis factor-related apoptosis-inducing ligand, TSLP thymic stromal lymphopoietin, VEGF vascular endothelial growth factor.