Table 2.

Association between echocardiographic ventricular dysfunction and serum markers adjusted for age and sex.

Serum marker	OR	95% CI	p-value
Left ventricular systolic dysfunction, GLS > -17%
ANGPT2 (n = 100)	3.42	1.52–7.71	0.003
OPN (n = 93)	1.95	1.08–3.52	0.026
Left ventricular diastolic dysfunction
ANGPT2 (n = 122)*	1.38	0.98–1.94	0.062*
Endostatin (n = 113)*	1.60	0.95–2.67	0.075*
TRAIL (n = 131)	0.41	0.21–0.78	0.007
Right ventricular systolic dysfunction, TAPSE < 17 mm
ANGPT2 (n = 153)	1.67	1.11–2.50	0.014
Endostatin (n = 143)	1.86	1.22–2.84	0.004
OPN (n = 143)	1.86	1.25–2.77	0.002
TRAIL (n = 163)	0.32	0.15–0.66	0.002

ANGPT2 angiopoietin 2, CI confidence interval, GLS global longitudinal strain, OPN osteopontin, OR odds ratio, TAPSE tricuspid annular plane systolic excursion, TRAIL tumor necrosis factor-related apoptosis-inducing ligand.

*Indicates numerical associations. HR of ANGPT2, Endostatin, OPN and TRAIL represent an increase of one standard deviation.