Table 4.
Prediction of mortality by ANGPT2 and TRAIL in multivariable cox regression.
| Multivariable cox regression on mortality | |||||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||
| ANGPT2 | 1.33 | 1.07–1.67 | 0.012 | TRAIL | 0.66 | 0.44–0.99 | 0.045 |
| Age | 1.07 | 1.04–1.10 | < 0.001 | Age | 1.07 | 1.04–1.09 | < 0.001 |
| Male sex | 1.18 | 0.63–2.22 | 0.598 | Male sex | 1.23 | 0.67–2.25 | 0.510 |
| mRSS | 1.05 | 1.02–1.08 | < 0.001 | mRSS | 1.04 | 1.01–1.06 | 0.005 |
| NT-proBNP | 1.01 | 1.01–1.01 | < 0.001 | NT-proBNP | 1.01 | 1.01–1.01 | < 0.001 |
| Precapillary PH | 2.54 | 1.44–4.48 | 0.001 | Precapillary PH | 2.03 | 1.19–3.46 | 0.009 |
| C-index | 0.83 | C-index | 0.82 | ||||
ANGPT2 angiopoietin 2, CI confidence interval, HR hazard ratio, mRSS modified Rodnan skin score, NT-proBNP N-terminal prohormone of brain natriuretic peptide, PH pulmonary hypertension, TRAIL tumor necrosis factor-related apoptosis-inducing ligand. The HR of ANGPT2 and TRAIL represent an increase of one standard deviation.