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. 2022 Mar 18;12:4696. doi: 10.1038/s41598-022-08210-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ESR1 and ESR2 mRNA expression in SCAN-B and TCGA data sets. (A) Scatterplot of ESR1 and ESR2 mRNA expression (log₂TPM). ESR1 and ESR2 data points are colored by density using 2D kernel density estimation function from the MASS R package. Adjacent to the scatterplot, histograms are shown indicating the frequency of expression values and color-coded according to ERα clinical status. (B) Expression of ESR1 and ESR2 is shown for the TCGA dataset as in panel A.