Fig. 1.

Functional connectivity differences between the three groups. Illustration of the differences functional connectivity (FC) patterns of the left habenula between the three groups: (a) the left and the right precuneus cortex and right precentral gyrus FC with the left habenula showed differences between the treatment-resistant depression (TRD) group and the treatment-sensitive depression (TSD) group (TRD > TSD) (superior view); (b) means of FC of the left habenula ot the combined clusters described at (a) for TRD, TSD and healthy controls (HC). The color scale bar on (a) represents the strength of the t statistic. The “mean FC” (mean functional connectivity) on (b) represents beta values of functional connectivity between the two regions.