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. 2022 Mar 18;12:4695. doi: 10.1038/s41598-022-08467-8

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(A) CD spectra of IGF-II (black), Q18I IGF-II (red), Q18M IGF-II (blue) and Q18Y IGF-II (grey). Percent helical content shown in the table was calculated using the CDSSTR algorithm for deconvolution against the reference protein database set SMP180. (B) Temperature denaturation assays monitored by ellipticity at 222 nm.