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. 2022 Feb 28;28:58–76. doi: 10.1016/j.omtn.2022.02.019

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Changes in gene expression caused by LVs encoding the U6-driven RNAi effectors

(A) Log2 fold change (log2FC) distribution for the genes that were downregulated in the ARPE19 cells transduced with the LVs encoding the U6-driven RNAi effectors, compared with the cells transduced with the LV/U6-agshS1. The inset shows the number of downregulated genes compared with the cells transduced with the LV/U6-agshS1. (B) As in (A), but with upregulated genes. EDCF, empirical cumulative distribution function.