Table 1.
Mendelian randomization results of causal risk proteins on childhood neurodevelopmental disorders.a,b
| Method | No. of SNPs | MR analysis |
Heterogeneity test |
MR-Egger intercept P | |||
|---|---|---|---|---|---|---|---|
| OR (95%) | P | Cochran's Q | I2 | P | |||
| MAPKAPK3 on ASD | |||||||
| IVW | 20 | 1.09(1.05,1.13) | 1.43e-06 | 15.2 | 0% | 0.710 | - |
| MR-Egger | 20 | 1.10(1.03,1.18) | 7.61e-03 | 15.2 | 0% | 0.711 | 0.843 |
| Weighted median | 20 | 1.09(1.04,1.15) | 3.03e-04 | - | - | - | - |
| MRPL33 on. ASD | |||||||
| IVW | 23 | 1.07(1.04,1.11) | 5.37e-06 | 16.3 | 0% | 0.800 | |
| MR-Egger | 23 | 1.12(1.07,1.17) | 5.63e-07 | 12.8 | 0% | 0.939 | 0.011 |
| Weighted median | 23 | 1.08(1.03,1.13) | 8.33e-04 | - | - | - | |
| MANBA on ADHD | |||||||
| IVW | 14 | 0.91(0.88,0.95) | 8.97e-06 | 15.1 | 13.6% | 0.304 | - |
| MR-Egger | 14 | 0.86(0.81,0.93) | 3.68e-05 | 11.2 | 0% | 0.596 | 0.072 |
| Weighted median | 14 | 0.89(0.85,0.94) | 3.65e-06 | - | - | - | - |
Abbreviations: MR, Mendelian Randomization; ASD, autism spectrum disorder; ADHD, attention-deficit hyperactivity disorder.
a
Results from 2-sample MR analysis; main analysis method: outliers identified and removed by MR PRESSO tool; estimated associations reported as OR of outcome per unit increase in log odds of the quantification of specific protein.
b
Genetic instruments selected from GWAS of plasma proteome, selection threshold P less than 1 × 10−5, pruned at linkage disequilibrium R2 less than .001 (10 megabytes pair window); No. of SNPs refers to the number of genetic instruments included in final MR analysis.