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. 2022 Mar 3;25(4):104004. doi: 10.1016/j.isci.2022.104004

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Characteristics of dynamic DMRs

(A) Percent of DMRs that are dynamic at each time point in the whole bone marrow from Dnmt3a^fl/fl + Tam (takeaway) and Dnmt3a^−/− + Dox (addback) mice. Dynamic DMRs are defined as those that have a change in beta value of >0.2 from baseline where baseline for takeaway and addback are defined as values in Dnmt3a^fl/fl – Tam (WT) and Dnmt3a^−/- for individual DMRs, respectively.

(B) Venn diagram showing overlap between dynamic DMRs identified in Dnmt3a^fl/fl + Tam (takeaway; red) and Dnmt3a^−/− + Dox (addback; blue) mice at week 1, and at weeks 22/24. The dynamic DMRs found in week 1 are classified as rapid dynamic DMRs.

(C) Example of a rapid dynamic DMR within the Meis1 gene. The gene structure is shown below, genomic location (assembly mm10) shown above, individual CpGs are represented by colored bars, y -axis is mean methylation of CpGs, time is given in weeks, and the DMR is highlighted in the gray box. DMR; differentially methylated region, Dox; doxycycline, tam; tamoxifen. Time is shown in weeks.