Table 2.
Summary of enzymes involved in protein acylations
| Acylations | Writers |
Erasers |
Readers |
||
|---|---|---|---|---|---|
| Family | Members | Family | Members | Members | |
| GNAT: GCN5, PCAF | HDAC1–10 | ||||
| ε-amino acetylation | KAT | CBP/p300 | KDAC | SIRT1–7 | BRDs, YEATS, PHD |
| MYST: MOZ, MOF, HBO1, Tip60 | |||||
| Formylation | NA | NA | NA | NA | NA |
| Nt-acetylation | NAT | NatA-F | NA | NA | NA |
| Propionylation | KAT | p300/CBP, PCAF, GCN5, MOF, HB01, MOZ | NA | NA | BRDs, YEATS |
| Butyrylation | KAT | p300/CBP, PCAF, GCN5 | NA | NA | YEATS |
| Malonylation | NA | NA | KDAC | SIRT5 | NA |
| Succinylation | NA | NA | KDAC | SIRT5, SIRT7 | NA |
| Glutarylation | NA | NA | KDAC | SIRT5 | NA |
| Palmitoylation | PAT | DHHC1–23 | APT | APT1–2 | NA |
| Myristoylation | NMT | NMT1–2 | NA | NA | NA |
| Benzoylation | NA | NA | KDAC | SIRT2 | NA |
| Crotonylation | KAT | P300/CBP, MOF | KDAC | HDAC1–3, SIRT1–3 | YEATS, PHD |
| 2-hydroxyisobutyrylation | KAT | P300/CBP, Tip60 | KDAC | HDAC2–3 | NA |
Abbreviations: GNAT, Gcn5-related N-acetyltransferase; NA, not available.