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Steady-state kinetic parameters of the purified FAR-1 β-lactamase
| Substrate | kcat (s−1) | Km (μM) | kcat/Km (μM · s−1) |
|---|---|---|---|
| Benzylpenicillin | 165 | 30 | 5.5 |
| Amoxicillin | 190 | 50 | 3.8 |
| Ticarcillin | 49.5 | 31 | 1.6 |
| Piperacillin | 412 | 45 | 9.2 |
| Cephalothin | 14 | 104 | 0.13 |
| Cephaloridine | 131 | >500 | <0.1 |
| Cefuroxime | 3.3 | >500 | <4 × 10−3 |
| Ceftazidime | NHa | NDb | ND |
| Cefotaxime | 5 | >500 | <6 × 10−3 |
| Aztreonam | 13.2 | 400 | <0.02 |
NH, not hydrolyzable.
ND, not detectable.
