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A schematic of ROS and ATF4 regulation by PRMT5 and EVI1. PRMT5 inhibition leads to unstable intron retaining ATF4 mRNA and low ATF4 protein levels, while overexpression of EVI1 also decreases ATF4 protein levels. Both, high EVI1 and PRMT5i result in a very low ATF4 state and increased intracellular ROS affecting cell proliferation, survival, and senescence.
