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. 2022 Mar 18;78:103943. doi: 10.1016/j.ebiom.2022.103943

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 2 — The antibacterial activity of tetracyclines and other antibiotics combined with plumbagin against tet(X3)/tet(X4)-positive strains. Microdilution checkerboard analysis showed that plumbagin restored the susceptibility of tet(X4)-carrying E. coli J53p47EC and K. pneumoniae K12016p47EC to tetracycline (a) and methacycline (b), in comparison to the tet(X4)-negative strains E. coli J53 and K. pneumoniae K12016. (c and d) FIC indices of the combination of plumbagin (32 μg/mL) and antibiotics of different types against tet(X3)/tet(X4)-positive strains. Synergy was defined as an FIC index of ≤ 0.5.