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. 2022 Mar 18;78:103943. doi: 10.1016/j.ebiom.2022.103943

Figure 8.

Fig 8

Synergistic mechanisms of plumbagin in combination with tetracycline. An accelerated TCA cycle was observed after the treatment with plumbagin (a) or the combination of plumbagin and tetracycline (b). (c and d) Plumbagin supplementation dramatically promoted the generation of ROS, whether it alone or combined with tetracycline. And the level of intracellular ATP in E. coli DH5α+pAM401-tet(X4) was further measured after coculture with plumbagin alone (e) or in combination with tetracycline (f). All of the data are representative of three independent experiments and presented as the mean ± SD. *p < 0.05, **p < 0.01 (Student's t test).