Table 2.
Panel A. Total Effect of ACEs on Depressive Symptoms | |||
---|---|---|---|
Total Effect | SE | p | |
1 ACE | 0.048 | 0.055 | 0.385 |
2 ACEs | 0.155 | 0.058 | 0.008 |
3 ACEs | 0.393 | 0.112 | <0.001 |
4+ ACEs |
0.387 |
0.108 |
<0.001 |
Panel B. Indirect Effects of ACEs on Depressive Symptoms via GrimAge | |||
Indirect Effect | 95% CI | ||
1 ACE | 0.020 | 0.011–0.035 | |
2 ACEs | 0.021 | 0.007–0.039 | |
3 ACEs | 0.034 | 0.019–0.058 | |
4+ ACEs |
0.051 |
0.023–0.090 |
|
Panel C. Indirect Effects of ACEs on Depressive Symptoms via DunedinPoAm38 | |||
Indirect Effect | 95% CI | ||
1 ACE | 0.008 | 0.002–0.020 | |
2 ACEs | 0.007 | 0.000–0.019 | |
3 ACEs | 0.009 | 0.001–0.024 | |
4+ ACEs |
0.027 |
0.006–0.058 |
|
Panel D. Indirect Effects of ACEs on Depressive Symptoms via PhenoAge | |||
Indirect Effect | 95% CI | ||
1 ACE | −0.001 | −0.009 - 0.003 | |
2 ACEs | 0.003 | −0.001 - 0.017 | |
3 ACEs | 0.007 | −0.001 - 0.024 | |
4+ ACEs | 0.002 | −0.003 - 0.011 |
Note: CI = confidence interval. 95% CIs were estimated using a bias corrected bootstrap procedure with 1000 draws. Epigenetic aging and depressive symptoms, but not ACESs, are standardized using the “STANDARDIZE” command in Mplus.