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. 2022 Mar 16;17:101071. doi: 10.1016/j.ssmph.2022.101071

Table 2.

Direct and indirect effects from structrual equation models.


Panel A. Total Effect of ACEs on Depressive Symptoms
Total Effect SE p
1 ACE 0.048 0.055 0.385
2 ACEs 0.155 0.058 0.008
3 ACEs 0.393 0.112 <0.001
4+ ACEs
0.387
0.108
<0.001
Panel B. Indirect Effects of ACEs on Depressive Symptoms via GrimAge
Indirect Effect 95% CI
1 ACE 0.020 0.011–0.035
2 ACEs 0.021 0.007–0.039
3 ACEs 0.034 0.019–0.058
4+ ACEs
0.051
0.023–0.090

Panel C. Indirect Effects of ACEs on Depressive Symptoms via DunedinPoAm38
Indirect Effect 95% CI
1 ACE 0.008 0.002–0.020
2 ACEs 0.007 0.000–0.019
3 ACEs 0.009 0.001–0.024
4+ ACEs
0.027
0.006–0.058

Panel D. Indirect Effects of ACEs on Depressive Symptoms via PhenoAge
Indirect Effect 95% CI
1 ACE −0.001 −0.009 - 0.003
2 ACEs 0.003 −0.001 - 0.017
3 ACEs 0.007 −0.001 - 0.024
4+ ACEs 0.002 −0.003 - 0.011

Note: CI = confidence interval. 95% CIs were estimated using a bias corrected bootstrap procedure with 1000 draws. Epigenetic aging and depressive symptoms, but not ACESs, are standardized using the “STANDARDIZE” command in Mplus.