Table 1.
Baseline characteristics of patients with IPF
| Value | |
|---|---|
| Number of patients with IPF | 1737 |
| Total follow-up period (patient-years) | 3720 |
| Median follow-up in years (IQR) | 2.0 (0.9–3.2) |
| Sociodemographic characteristics at index date | |
| Male sex, n (%) | 1173 (67.5) |
| Age at index date (years), mean (SD) | 72.1 (10.4) |
| Insurance status at index date, n (%) | |
| Retired | 1489 (85.7) |
| Employed | 143 (8.2) |
| Unemployed | 51 (2.9) |
| Voluntarily insured | 37 (2.1) |
| Family-insured | 17 (1.0) |
| Comorbidities in baseline period | |
| CCI score at index date, median (IQR) | 4.0 (2.0–6.0) |
| Lung cancer, n (%) | 106 (6.1) |
| COPD, n (%) | 691 (39.8) |
| Asthma, n (%) | 282 (16.2) |
| Heart failure, n (%) | 622 (35.8) |
| Arterial hypertension, n (%) | 1411 (81.2) |
| Type 2 diabetes mellitus, n (%) | 647 (37.2) |
| GERD, n (%) | 418 (24.1) |
| Chronic ischemic heart disease, n (%) | 667 (38.4) |
| Dyslipidemia, n (%) | 889 (51.2) |
| Outpatient visits, hospitalizations, and procedures in baseline period | |
| Number of GP visits per patient, mean (SD) | 4.6 (1.8) |
| Number of pulmonologist visits per patient, mean (SD) | 0.9 (1.2) |
| Number of other specialist visits per patient, mean (SD) | 10.1 (6.2) |
| Number of all-cause hospitalizations per patient, mean (SD) | 1.1 (1.8) |
| Number of days spent in hospital per patient, mean (SD) | 8.2 (18.5) |
| Lung transplant, n (%) | 7 (0.4) |
| Top five prescribed drug classes in baseline period, n (%) | |
| Proton pump inhibitors | 787 (45.3) |
| Beta blocking agents, selective | 774 (44.6) |
| Statins | 641 (36.9) |
| Sulfonamide-diuretics, plain | 590 (34.0) |
| Pyrazalones | 518 (29.8) |
| Top five inpatient main diagnoses in baseline period, n (%) | |
| Pneumonia | 102 (5.9) |
| Heart failure | 90 (5.2) |
| COPD | 65 (3.7) |
| Neoplasm of uncertain behavior of middle ear and respiratory and intrathoracic organs | 41 (2.4) |
| Chronic ischemic heart disease | 36 (2.1) |
The respective baseline period is 12 months prior to the index date. “Retired” includes pension applicants; For the respective ATC, OPS, and ICD-10-GM codes, see Additional file 1: Table S3
ATC Anatomical Therapeutic Chemical, CCI Charlson Comorbidity Index, COPD chronic obstructive pulmonary disease, GERD gastroesophageal reflux disease, GP general practitioner, ICD-10-GM German Modification of the International Classification of Diseases, IPF idiopathic pulmonary fibrosis, IQR interquartile range, OPS Operationen-und Prozedurenschlüssel/operation and procedure classification, SD standard deviation