Fig. 1.

Flow chart of study population. AKI was defined in children according to the original KDIGO definition or a modified definition (sKDIGO) where children with a 1.5-fold increase in serum creatinine (SCr) from 0.2 to 0.3 mg/dL was not considered AKI. AKI status was defined as admission AKI if a child met criteria for AKI using the admission SCr based on the nadir SCr measured over hospitalization or incident AKI in children whom did not have AKI on admission but developed it over hospitalization. When assessing the incidence of AKI over hospitalization, children with AKI present on admission were excluded from the denominator. *Children with a maximum AKI stage higher than the admission AKI stage were considered to have worsening AKI