Table 2.
The pulmonary function parameters that significantly associated with survival after adjustment for possible influencing factorsa
| pulmonary function parameter | β | SE | Wald | P* | HR(95%CI)* |
|---|---|---|---|---|---|
| FVC | |||||
| > 86.42 | 1.000 | ||||
| 66.82–86.42 | 0.467 | 0.232 | 4.068 | 0.044 | 1.595(1.013,2.511) |
| < 66.82 | 1.202 | 0.245 | 24.045 | < 0.001 | 3.326(2.057,5.377) |
| FEV1 | |||||
| > 90.74 | 1.000 | ||||
| 72.62–90.74 | 0.277 | 0.223 | 1.537 | 0.215 | 1.319(0.851,2.044) |
| < 72.62 | 1.286 | 0.239 | 28.909 | < 0.001 | 3.618(2.264,5.781) |
| PEF | |||||
| > 87.40 | 1.000 | ||||
| 63.18–87.40 | 0.679 | 0.230 | 8.696 | 0.003 | 1.971(1.256,3.094) |
| < 63.18 | 1.339 | 0.259 | 26.828 | < 0.001 | 3.816(2.299,6.334) |
| MEF75% | |||||
| > 91.02 | 1.000 | ||||
| 66.26–91.02 | 0.639 | 0.222 | 8.270 | 0.004 | 1.894(1.226,2.928) |
| < 66.26 | 0.824 | 0.251 | 10.765 | 0.001 | 2.280(1.393,3.730) |
| MVV | |||||
| > 71.15 | 1.000 | ||||
| 42.41–71.15 | 0.925 | 0.230 | 16.164 | < 0.001 | 2.522(1.607,3.959) |
| < 42.41 | 1.460 | 0.251 | 33.780 | < 0.001 | 4.308(2.632,7.049) |
Abbreviation: HR Hazard Ratio, FVC Forced Vital Capacity, FEV1 Forced Expiratory Volume in 1 s, PEF Peak Expiratory Flow, MEF75% Maximal Expiratory Flow at 75% of FVC, MVV Maximal Voluntary Ventilation
a Possible influencing factors included sex, age of onset, site of onset, BMI, use of riluzole, acceptance of PEG, use of NIPPV, smoking, hypertension, diabetes mellitus, ALSFRS-R score at pulmonary function test, progression rate (ΔALSFRS-R), and time interval between disease onset and pulmonary function test
* Multivariate Cox survival analysis, Backward Stepwise (Wald)