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. 2022 Mar 19;21:80. doi: 10.1186/s12943-022-01560-6

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© The Author(s) 2022, corrected publication 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CircRNA expression profiling revealed that circALG1 is highly expressed in CRC. A Human circRNA microarray detection of circRNA expression in 3 pairs of cancer and paracancerous tissues from patients with CRC. B Human circRNA microarray detection of circRNA expression in 3 pairs of peripheral blood samples from normal individuals and patients with CRC. C Venn diagram of highly expressed circRNAs in both CRC tissues and peripheral blood. D Expression level of circALG1 in the GSE126094 dataset of the GEO. E qRT-PCR detection of the circALG1 expression levels in 40 pairs of CRC tumours and adjacent tissues. F qRT-PCR detection of the circALG1 expression levels in the peripheral blood of patients with CRC and normal individuals. G qRT-PCR detection of the circALG1 expression levels in the peripheral blood of patients with CRC before and 1 week after surgery. H-J ROC curves illustrating the discriminative capacity of circALG1 to distinguish between tumours and adjacent tissues from patients with CRC (H), between the peripheral blood of patients with CRC and that from healthy individuals (I), and between preoperative and postoperative peripheral blood samples from patients with CRC (J). The results are presented as the mean ± s.d. and are representative of at least 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ^#p > 0.05