Fig. 3.

circALG1 promoted CRC metastasis in vivo. A Representative images and bar graphs of Transwell migration and invasion assays of HCT116 cells with or without circALG1 overexpression (A) and SW480 cells with or without circALG1 silencing (sh-circALG1) (B). C-D Representative images and bar graphs of liver and lung metastases with circALG1-overexpressing HCT116 cells (C) and circALG1-silenced SW480 cells (D) in a nude mouse metastatic tumour model. The results are presented as the mean ± s.d. and are representative of at least 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ^#p > 0.05