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. 2022 Mar 19;21:80. doi: 10.1186/s12943-022-01560-6

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© The Author(s) 2022, corrected publication 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CircALG1 promoted migration and invasion through miR-342-5p in CRC. A Luciferase expression was normalized to Renilla luciferase expression, and the relative luciferase activity of miRNA mimic-transfected wells was compared with the control luciferase levels. B The luciferase activities were measured by a dual-luciferase assay, and the Renilla/firefly luciferase light-unit ratio was calculated. C qRT-PCR detection of miR-342-5p enrichment by circALG1 RAP assay. D-E Representative images and bar graphs of Transwell migration and invasion assays of cells with circALG1 overexpression and treatment with the miR-342-5p inhibitor (D) and cells with circALG1 inhibition and treatment with miR-342-5p mimics (E). The results are presented as the mean ± s.d. and are representative of at least 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ^#p > 0.05