Table 3.
Multivariable competing risk models for likelihood of living donor liver transplant
| Univariable Effects | Race + Deprivation | Race + Deprivation + Insurance | Race + Deprivation + Initial Lab MELD/PELD + Insurance | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
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| Variable | SHR | 95% CI | P Value | SHR | 95% CI | P Value | SHR | 95% CI | P Value | SHR | 95% CI | P Value |
| Race/ethnicity | ||||||||||||
| Non-Hispanic White | REF | REF | REF | REF | ||||||||
| Black | 0.58 | 0.45, 0.75 | <0.001 | 0.70 | 0.54, 0.90 | 0.01 | 0.83 | 0.64, 1.07 | 0.15 | 0.79 | 0.60, 1.02 | 0.08 |
| Hispanic | 0.61 | 0.49, 0.75 | <0.001 | 0.73 | 0.59, 0.92 | 0.01 | 0.91 | 0.72, 1.14 | 0.41 | 0.89 | 0.70, 1.11 | 0.30 |
| Other | 0.80 | 0.60, 1.07 | 0.14 | 0.80 | 0.60, 1.08 | 0.14 | 0.85 | 0.63, 1.14 | 0.28 | 0.83 | 0.62, 1.11 | 0.21 |
| Neighborhood deprivation | 0.77 | 0.72, 0.84 | <0.001 | 0.81 | 0.75, 0.88 | <0.001 | 0.90 | 0.83, 0.98 | 0.02 | 0.90 | 0.83, 0.98 | 0.01 |
| Insurance | ||||||||||||
| Private | REF | REF | REF | |||||||||
| Public | 0.39 | 0.33, 0.47 | <0.001 | 0.45 | 0.37, 0.54 | <0.001 | 0.45 | 0.37, 0.55 | <0.001 | |||
| Other | 0.62 | 0.36, 1.08 | 0.09 | 0.65 | 0.37, 1.13 | 0.13 | 0.66 | 0.38, 1.16 | 0.15 | |||
| Initial Lab MELD/PELD | 1.01 | 1.01, 1.02 | <0.001 | 1.01 | 1.01, 1.02 | <0.001 | ||||||
Abbreviations: MELD, Model for End-Stage Liver Disease; PELD: Pediatric End-Stage Liver Disease; REF: Reference category; SHR: subhazard ratio
To better understand the effect of race/ethnicity on waitlist mortality, we used a hypothesized causal model (Figure 1) to select the set of co-variates for the models. In these models, we included neighborhood deprivation, insurance status, and initial PELD/MELD (as a surrogate for disease severity at the time of listing).