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. Author manuscript; available in PMC: 2022 Mar 19.
Published in final edited form as: Nature. 2021 Jul 14;595(7869):701–706. doi: 10.1038/s41586-021-03734-6

Extended Data Table 4. Missense mutations detected in CRISPR Cas9 edited mice.

Missense mutations do not influence EGFP signal in Il3 targeted mice but result in quenching of EGFP signaling in Il3rɑ targeted mice. IL-3Rɑ functionality is not impacted (Extended Data Fig. 3i).

Mouse line Element of donor in which missense mutation was detected Missense mutations detected
Il3GFPfl/fl Il3 cDNA D70Y (GAT>TAT)
eGFP E143D (GAG>GAT)
Il3rɑfl/fl Il3ra cDNA W295L (TGG>TTG)
eGFP G41C (GGC>TGC), E173Q (GAG>CAG) and A228S (GCC>TCC)