Table 2.
Baseline Characteristics of the Patients with Different Frailty Status
| Characteristics | Total (n=204) | Frailty Status | P-value | ||
|---|---|---|---|---|---|
| No Frailty (n=16) | Pre-Frailty (n=41) | Frailty (n=147) | |||
| Demographic | |||||
| Age, years | 71.65±5.89 | 68.81±5.29 | 64.80±4.81 | 73.86±4.47 | 0.001 |
| Gender, female | 91(44.6) | 4(25.0) | 15(36.6) | 72(49.0) | 0.096 |
| Married | 183(89.7) | 15(93.8) | 37(90.2) | 131(89.1) | 0.839 |
| Education level | 0.014 | ||||
| Primary school (<6 years) | 12(5.9) | 2(12.5) | 1(2.4) | 10(6.8) | |
| Middle school (6–12 years) | 133(65.2) | 8(50.0) | 21(51.2) | 103(70.1) | |
| Higher education (>12 years) | 59(28.9) | 6(37.5) | 19(46.3) | 34(23.1) | |
| Smoking history | 95(46.6) | 7(43.8) | 21(51.2) | 67(45.6) | 0.792 |
| Alcohol intake | 78(38.2) | 7(43.8) | 20(48.8) | 51(34.7) | 0.233 |
| Medical history | |||||
| Hypertension | 177(86.8) | 13(81.3) | 34(82.9) | 130(88.4) | 0.537 |
| Diabetes | 84(41.2) | 2(12.5) | 15(36.6) | 67(45.6) | 0.031 |
| Stroke | 31(15.2) | 3(18.8) | 6(14.6) | 22(15.0) | 0.921 |
| CHD | 65(31.9) | 3(18.8) | 11(26.8) | 51(34.7) | 0.318 |
| MoCA<26 | 130(63.7) | 9(56.3) | 30(73.2) | 91(61.9) | 0.336 |
| Dialysis vintage, mo. | 59.00(21.00, 99.50) | 20.00(7.00, 63.50) | 34.00(12.00, 90.00) | 65.00(28.50, 106.00) | 0.005 |
| Single-pool Kt/V | 1.29±0.17 | 1.35±0.15 | 1.34±0.13 | 1.27±0.18 | 0.019 |
| nPCR, g/(kg·d) | 0.98±0.15 | 0.99±0.14 | 0.99±0.11 | 0.98±0.16 | 0.132 |
| BMI, kg/m2 | 23.95±4.28 | 26.18±8.59 | 23.98±3.69 | 23.7±3.68 | 0.089 |
| Laboratory | |||||
| Hb, g/L | 110.24±13.33 | 111.56±15.60 | 111.68±10.29 | 109.69±13.81 | 0.645 |
| Alb, g/L | 37.67±3.35 | 40.84±3.09 | 39.44±3.25 | 36.84±3.02 | 0.000 |
| CPK, U/L | 210.22±23.30 | 221.06±25.00 | 211.76±18.43 | 209.78±21.80 | 0.725 |
| TC, mmol/L | 4.22±1.39 | 4.28±0.90 | 4.06±0.82 | 4.26±1.55 | 0.706 |
| TG, mmol/L | 1.99±1.22 | 2.28±1.39 | 1.95±1.12 | 1.97±1.23 | 0.611 |
| Calcium, mmol/L | 2.23±0.25 | 2.19±0.17 | 2.20±0.25 | 2.24±0.25 | 0.511 |
| Phosphate, mmol/L | 1.73±0.72 | 1.69±0.44 | 1.84±0.77 | 1.71±0.73 | 0.569 |
| iPTH, pg/mL | 164.90(85.33, 270.20) | 116.10(38.66226.25) | 162.80(102.9, 255.50) | 166.30(88.20, 282.55) | 0.287 |
| CRP, mg/L | 2.7(1.31, 5.55) | 1.78(1.14, 4.63) | 2.77(1.26, 5.00) | 2.70(1.39, 5.72) | 0.777 |
| EPO dosage, u/W | 7500(6000,9000) | 9000(6750,9000) | 7500(6000,9000) | 7500(6000,9000) | 0.198 |
Note: Values are shown as mean ± standard deviation or median [interquartile range: 25th to 75th percentiles] or n (%).
Abbreviations: CHD, coronary heart disease; MoCA, Montreal Cognitive Assessment; Kt/V, an indicator for evaluating dialysis adequacy; nPCR, normalized protein catabolic rate; BMI, body mass index; Hb, hemoglobin; ALB, albumin; CPK, creatine phosphokinase; TC, total cholesterol; TG, triglyceride; iPTH, intact parathyroid hormone; CRP, C-reactive protein; EPO, erythropoietin.