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. 2022 Mar 18;32(3):033123. doi: 10.1063/5.0085291

FIG. 2.

FIG. 2.

Automaticity in identical cells for high IK1 current at the cleft. The time series for the (a) lateral segment voltage, (b) cleft voltage, (c) cleft potassium concentration, IK1 at the (d) lateral segment and (e) junctional membrane, sodium current INa at the (f) lateral segment and (g) junctional membrane, and (h) lateral segment slow-inward current Isi, for the junctional membrane fraction of IK1 ( fK1) of 0.7 (black) and 0.9 (green). Higher fK1 triggered automaticity and synchronized APs in both cells, due to cleft potassium accumulation, increasing the resting potential to trigger inward Isi.