Inhibition of p300 attenuates DR and biliary fibrosis in Mdr−/− mice. (A) Masson’s Trichrome staining (Unpaired Student's t-test *p<0.05); (B-C) qRT-PCR for Epcam, Ncam, Krt19 and Krt7 (Unpaired Student's t-test *p<0.05,**p<0.01); (D) Immunohistochemistry for CK19 Mann-Whitney test *p<0.05); (E-F) qRT-PCR analysis for Afp, Trop2, and Ki-67 in liver from Mdr−/− mice treated with vehicle or SGC-CBP30 (Unpaired Student's t-test *p<0.05,**p<0.01). (n=3-4 animals/group). Graph bars represent SEM.