Table 3:
Mean volumetric brain measures (SEM) of n=1,306 MRI cohort by PPC at Visit 5, ARIC
| Categories of Periodontal Profile Class | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Healthy | Mild Disease | High GI | Tooth Loss | Posterior Disease | Severe Tooth Loss | Severe Disease | Edentulous | p-value | |
| N | 347 | 200 | 140 | 106 | 125 | 151 | 82 | 155 | N=1306 |
| Total Brain Volume (cm3) | |||||||||
| Crude | 1028.20 (5.92) | 1033.38 (7.64) | 993.83 (9.24) | 1011.08 (10.48) | 1057.54 (9.80) | 991.95 (8.51) | 1009.60 (11.89) | 969.75 (8.07) | <0.01* |
| Model 1 | 1017.11 (2.90) | 1018.11 (3.61) | 1022.31 (4.78) | 1016.66 (4.82) | 1011.18 (4.63) | 1015.02 (4.03) | 1013.16 (5.57) | 1011.47 (3.90) | 0.62 |
| Model 2 | 1014.73 (2.92) | 1016.24 (3.56) | 1021.80 (4.67) | 1017.66 (4.73) | 1009.40 (4.57) | 1016.90 (4.00) | 1014.42 (5.46) | 1017.65 (4.32) | 0.79 |
| Temporal-Parietal Meta ROI Volume (cm3) | |||||||||
| Crude | 60.11 (0.38) | 60.25 (0.49) | 57.34 (0.59) | 58.82 (0.67) | 61.93 (0.63) | 57.07 (0.55) | 58.40 (0.76) | 56.00 (0.52) | <0.01* |
| Model 1 | 59.29 (0.33) | 58.66 (0.40) | 59.12 (0.54) | 59.16 (0.54) | 59.51 (0.519) | 58.50 (0.45) | 58.16 (0.62) | 58.02 (0.44) | 0.24 |
| Model 2 | 59.26 (0.33) | 58.67 (0.40) | 59.16 (0.53) | 59.33 (0.54) | 59.38 (0.52) | 58.49 (0.45) | 58.24 (0.62) | 58.06 (0.49) | 0.42 |
Abbreviations: PPC = Periodontal Profile Class; GI = Gingival Inflammation; ROI = Regions of Interest.
Temporal-parietal meta ROI outcome is comprised of combined volumetric measures of parahippocampal, entorhinal, inferior parietal lobules, hippocampus, and pre-cuneus brain regions.
P-values are from tests for significant difference between PPC levels.
Denotes significant p-values (p<0.05).
Estimates of mean volumetric brain measures were computed via multiple linear regression.
Model 1: crude + age + sex + education + race + income + insurance + APOE ε4 allele presence + total intracranial volume
Model 2: Model 1 + body mass index + physical activity + smoking status + LDL cholesterol + prevalent heart failure + anti-hypertensive medication + prevalent coronary heart disease + prevalent stroke + prevalent diabetes + systolic blood pressure + dental visit frequency.
Note: Total brain volume was additionally adjusted for total intracranial volume starting in Model 1.