Table 4:
Adjusted odds ratios (95% CIs) for cerebrovascular outcomes of n=1,306 MRI cohort by PPC at Visit 5, ARIC
| Categories of Periodontal Profile Class | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Healthy | Mild Disease | High GI | Tooth Loss | Posterior Disease | Severe Tooth Loss | Severe Disease | Edentulous | p-value | |
| N | 347 | 200 | 140 | 106 | 125 | 151 | 82 | 155 | N=1306 |
| Microhemorrhages | |||||||||
| All type | ref. | 1.43 (0.93, 2.21) | 1.15 (0.66, 2.02) | 1.11 (0.64, 1.94) | 0.67 (0.37, 1.19) | 0.76 (0.44, 1.31) | 1.14 (0.61, 2.13) | 1.55 (0.89, 2.69) | 0.07 |
| Subcortical | ref. | 1.45 (0.91, 2.31) | 1.38 (0.77, 2.50) | 1.37 (0.77, 2.43) | 0.67 (0.35, 1.28) | 0.84 (0.47, 1.50) | 1.37 (0.71, 2.64) | 1.29 (0.71, 2.33) | 0.19 |
| Lobar | ref. | 1.31 (0.67, 2.57) | 0.82 (0.33, 2.01) | 0.73 (0.27, 1.98) | 0.65 (0.26, 1.64) | 0.92 (0.40, 2.08) | 0.75 (0.27, 2.05) | 1.10 (0.46, 2.63) | 0.83 |
| Infarctions | |||||||||
| All type | ref. | 0.67 (0.42, 1.08) | 1.00 (0.56, 1.79) | 1.42 (0.84, 2.41) | 0.83 (0.49, 1.40) | 0.37 (0.20, 0.65) | 0.93 (0.50, 1.73) | 0.56 (0.31, 0.99) | <0.01* |
| Cortical | ref. | 1.14 (0.64, 2.03) | 0.68 (0.30, 1.51) | 1.52 (0.78, 2.97) | 0.62 (0.29, 1.33) | 0.37 (0.16, 0.87) | 0.54 (0.21, 1.36) | 0.76 (0.34, 1.71) | 0.06 |
| Subcortical | ref. | 0.52 (0.30, 0.90) | 0.98 (0.51, 1.87) | 1.02 (0.56, 1.85) | 0.74 (0.41, 1.35) | 0.36 (0.19, 0.67) | 1.00 (0.51, 1.97) | 0.36 (0.19, 0.68) | <0.01* |
| Lacunar | ref. | 0.50 (0.29, 0.87) | 0.99 (0.52, 1.89) | 1.01 (0.56, 1.85) | 0.66 (0.36, 1.22) | 0.34 (0.18, 0.64) | 1.03 (0.53, 2.02) | 0.34 (0.18, 0.66) | <0.01* |
Abbreviations: PPC = Periodontal Profile Class; CI = confidence intervals; GI = gingival inflammation.
P-values are from tests for significant difference of odds between PPC levels.
Denotes significant p-values (p<0.05). Bold typeface indicates significant 95% confidence intervals.
Odds ratio estimates shown are from full multivariable logistic regression models. Covariables of age, sex, education, race, income, insurance status, APOE ε4 allele presence, body mass index, physical activity, smoking status, LDL cholesterol, prevalent heart failure, anti-hypertensive medication use, prevalent coronary heart disease, prevalent stroke, prevalent diabetes, systolic blood pressure, and dental visit frequency were adjusted.