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. Author manuscript; available in PMC: 2023 Mar 20.
Published before final editing as: Psychoneuroendocrinology. 2021 Sep 20;134:105404. doi: 10.1016/j.psyneuen.2021.105404

Figure 4.

Figure 4.

Central serotonin turnover is impacted similarly by peripheral LPS treatment between BDNF heterozygous and control mice. Whole brain tissues collected 24h post injections were analyzed for serotonin metabolites to determine the impact of peripheral inflammation. Panels represent brain concentrations (μM) of (A) serotonin, (B) 5-hydroxyindoleacetic acid (5-HIAA) and (C) 5-HIAA/serotonin ratio. Data represent sample means ± SEM. n = 5–8 samples/group.

* = main effect (treatment or genotype)

*p<0.05–0.01 **p<0.01–0.001 ***p<0.001