Table 3.

Correlates of overall survival

	Univariate		Multivariable (n=588)
Variable	HR	95% CI	aHR	95% CI
Female sex	0.93	0.75 – 1.15	0.95	0.76 – 1.19
Age	1.01	0.996 – 1.02	1.01	1.00 – 1.02
Race/ethnicity
White	Ref	Ref	Ref	Ref
Black	1.08	0.86 – 1.36	1.01	0.79 – 1.28
Hispanic	1.01	0.79 – 1.28	0.67	0.52 – 0.87
Asian	0.67	0.37 – 1.21	0.85	0.46 – 1.55
Liver disease etiology
HCV	Ref	Ref
Alcohol	1.09	0.83 – 1.43
NASH	1.13	0.86 – 1.49
HBV	0.92	0.61 – 1.40
Other	0.76	0.41 – 1.43
Child Pugh
A	Ref	Ref	Ref	Ref
B	1.93	1.58 – 2.35	1.66	1.33 – 2.06
C	2.04	1.45 – 2.85	0.71	0.35 – 1.46
Ascites
None	Ref	Ref
Controlled	1.60	1.31 – 1.96
Uncontrolled	2.07	1.41 – 3.03
Hepatic encephalopathy
None	Ref	Ref
Controlled	1.16	0.92 – 1.46
Uncontrolled	2.19	0.98 – 4.91
AFP (ng/mL), n (%)
<20	Ref	Ref	Ref	Ref
20–200	1.26	1.00 – 1.59	1.29	1.01 – 1.65
>200	2.95	2.35 – 3.71	1.83	1.41 – 2.37
BCLC stage at diagnosis
0/A	Ref	Ref	Ref	Ref
B	2.29	1.77 – 2.95	1.76	1.34 – 2.31
C	5.98	4.63 – 7.71	3.88	2.75 – 5.47
D	2.47	1.76 – 3.46	2.94	1.43 – 6.03
Tumor number
1	Ref	Ref
2	1.36	1.06 – 1.76
3 or more	1.87	1.37 – 2.55
TNTC/infiltrative	5.04	3.75 – 6.76
Maximum tumor diameter
<2 cm	Ref	Ref
2–5 cm	1.49	1.12 – 1.98
>5 cm	4.19	3.08 – 5.72
Most Definitive HCC Treatment
Surgical	Ref	Ref	Ref	Ref
Locoregional	3.73	2.79 – 5.00	4.10	3.00 – 5.59
Systemic	9.54	6.33 – 14.39	3.59	2.20 – 5.86
None/BSC	17.41	12.48 – 24.29	12.65	8.65 – 18.50
Weight change prior to HCC diagnosis
None/weight gain	Ref	Ref	Ref	Ref
<5% weight loss	1.10	0.88 – 1.36	1.30	1.02 – 1.65
>5% weight loss	1.56	1.23 – 1.97	1.43	1.11 – 1.84

AFP – alpha-fetoprotein; CI – confidence interval; HBV – hepatitis B virus; HCV – hepatitis C virus; NASH – nonalcoholic steatohepatitis; OR – odds ratio; TNTC – too numerous to count