Table 1.

Antimicrobial susceptibility of the Salmonella Typhimurium SL1344 Δ4PAP strain complemented with F292V, Q311F or K366D AcrA to drugs with different physicochemical characteristics.

Strain	MIC (μg mL−1)
	HMMD				LMMD				PAC
	ERY	DOX	FA	NOV	CHL	CLI	MIN	LZD	ACR	BZK	BER	CV	EtBr	MB	R6G
WT	128	1024	1024	512	4	512	2	512	256	64	> 1024	64	1024	1024	1024
Δ4PAP	4	2	8	2	0.5	4	0.25	16	16	4	128	2	16	8	4
WT AcrA complement	64	64	256	64	4	128	1	128	64	32	> 1024	16	128	128	128
F292V AcrA	4	2	8	2	0.5	4	0.25	16	16	4	128	2	16	8	4
Q311F AcrA	64	64	256	64	4	128	1	128	64	32	> 1024	16	64	128	128
K366D AcrA	16	16	32	16	1	32	0.25	16	64	32	> 1024	16	64	128	64

Underlined values highlight values for the Δ4PAP strain complemented with wild type AcrA (WT complement). Bold values are at least two-fold or more different than the parent strain.

HMMD, high-molecular-mass drug; ERY, erythromycin; DOX, doxorubicin; FA, fusidic acid; NOV, novobiocin; LMMD, low-molecular-mass drug; CHL, chloramphenicol; CLI, clindamycin; MIN, minocycline; LZD, linezolid; PAC, planar aromatic cation; ACR, acriflavine; BZK, benzalkonium chloride; BER, berberine; CV, crystal violet; EtBr, ethidium bromide; MB, methylene blue; R6G, rhodamine 6G.