Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 5;13(4):258–280. doi: 10.1007/s13238-020-00794-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Model of tug-of-war regulation of 3D chromatin structure by inner and peripheral nuclear matrix proteins. A model describing lamin B1 tethering chromatin to the nuclear periphery and acting tug-of-war with the nuclear matrix pulling chromatin towards the nuclear interior to coordinate the establishment and maintenance of proper chromatin higher-order structure and dynamics. Loss of lamin B1 in lamina releases a fraction of LADs from the nuclear periphery to nuclear interior, which leads to gain of loosely folded chromatin in nucleoplasm. The change of chromosome compaction state induces expansion of chromosome territories and thus increases the interaction ratio between different chromosomes. Besides, loss of grab on specific LADs reduces the integrity and segregation of chromatin compartments and part of genomic regions switches between A and B compartments. Furthermore, depletion of lamin B1 can increase genomic loci dynamics. The dynamic motion of the same locus in different subnuclear regions demonstrates significant difference, and nuclear periphery-localized loci is much less mobile than the nucleoplasmic-positioned loci. Besides, chromatin compaction is a more fundamental factor affecting chromatin dynamics. Genomic loci in less compact compartment A are of higher mobility than those in more compact compartment B