TABLE 2.
Values of pharmacokinetic parameters for amprenavir after administration of escalating single, oral doses to 12 subjectsa
| Dose of amprenavir (mg) | AUC0–∞ (h · μg/ml) | Cmax (μg/ml) | Cmax/C12 | Tmax (h) | t1/2 (h) | Vz/F (liters) | CL/F (ml/min) | CLR (ml/min) |
|---|---|---|---|---|---|---|---|---|
| 150 | 4.03 (55) | 2.00 (57) | 112 (77) | 1.13 (34) | 7.95 (62) | 482 (57) | 808 (57) | 3.37 (36) |
| 300 | 9.13 (56) | 3.51 (44) | 48 (43) | 1.31 (35) | 7.08 (50) | 460 (76) | 757 (62) | 3.07 (48) |
| 600 | 21.16 (60) | 6.27 (52) | 29 (50) | 1.56 (37) | 8.00 (41) | 429 (58) | 651 (59) | 3.71 (24) |
| 900 | 32.73 (49) | 7.76 (31) | 19 (43) | 1.92 (35) | 7.83 (48) | 336 (41) | 547 (42) | 3.86 (24) |
| 1,200 | 47.14 (46) | 9.11 (30) | 18 (39) | 2.09 (38) | 9.54 (71) | 388 (75) | 519 (49) | 4.70 (35) |
a
All values are means, given together with percent coefficient of variance in parentheses.