Table 4.

Univariable and multivariable analyses of DFS in Luminal BC with HER2-negativity.

Characteristics	n	Univariate analysisHR (95% CI)	p-Value	Multivariate analysisHR (95% CI)	p-Value
Age (years)			0.337
<50	346	1
≥50	362	1.246 (0.795-1.955)
BMI			0.766
<24	446	1
≥24	262	1.072 (0.678-1.695)
Menopausal status			0.669
Pre-	362	1
Post-	327	1.104 (0.702-1.736)
Tumor size			<0.001		0.229
<2cm	449	1		1
≥2cm	259	2.431 (1.548-3.818)		1.824 (0.685-4.856)
Lymph node metastasis			<0.001		0.348
Negative	607	1		1
Positive	101	4.567 (2.894-7.206)		1.567 (0.613-4.007)
TNM grade
I	422	1		1
II	224	1.474 (0.843-2.576)	0.174	0.629 (0.200-1.981)	0.428
III	62	8.659 (5.098-14.706)	<0.001	1.740 (0.419-7.232)	0.446
Histology type
Infiltrating ductal carcinoma	635	1	0.954
Infiltrating lobular carcinoma	15	0	0.722
Others	57	1.152 (0.530-2.505)
Luminal subtype			0.054
Luminal A	316	1
Luminal B	392	1.591 (0.992-2.552)
Operation type
Modified radical mastectomy	375	1		1
Breast-conserving surgery	249	0.393 (0.218-0.709)	0.002	0.651 (0.343-1.236)	0.189
Mammectomy	72	0.193 (0.047-0.794)	0.023	0.338 (0.079-1.440)	0.142
Others	12	9.573 (4.696-19.518)	<0.001	5.444 (2.253-13.155)	<0.001
Chemotherapy
Neoadjuvant chemotherapy	66	1		1
Adjuvant chemotherapy	362	0.304 (0.174-0.530)	<0.001	0.882 (0.444-1.751)	0.719
No chemotherapy	280	0.242 (0.131-0.447)	<0.001	0.894 (0.362-2.210)	0.809
Radiotherapy			0.506
No	310	1
Yes	398	0.859 (0.550-1.344)
NLR			<0.001		<0.001
<2.2	423	1		1
≥2.2	285	3.321 (2.061-5.352)		2.886 (1.756-4.745)
CAR			<0.001		<0.001
<0.07	610	1		1
≥0.07	98	5.624 (3.577-8.841)		3.858 (2.346-6.345)

All of our variables with p-values less than 0.05 are in bold.