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Pathological detection of TA IA in patients with OA. A Pattern diagram. B H&E, Safranin O, and Masson stain. Immunohistochemical staining of SOX9, MMP13, P16, P21, and Ki67 of knee cartilage in the different groups. The cartilage layer (CL) is between the white dotted lines. Bar = 100 μm, n = 5 (C–H). Statistical analysis of OARSI scores, SOX9, MMP13, Ki67, P21, and P16. ****P < 0.0001, N = no statistical difference
