Fig. 5.

Combination of WNT974 and ART exhibits a potent anti-CRC effect in vivo. A The photographs of the CRC-bearing xenograft mouse model in different treatment groups. B Tumor volume, C % increase in tumor growth and D body weight of the mice. E Protein expressions of KRAS, β-TrCP, GSK-3β and ANAPC2 in the tumor tissues. F IHC analysis of the tumor tissues for KRAS, β-TrCP and GSK-3β (magnification × 200, Scale bars, 100 μm). Shown is mean ± SE, n = 5 mice in each group, *p < 0.05, **p < 0.01, *** p < 0.001 compared to control; a < 0.05, aa < 0.01, aaa < 0.001, compared to ART; b < 0.05, bb < 0.01, bbb < 0.001 compared to WNT974