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A schematic diagram showing the mechanism of action underlying the synergistic effect of the combination treatment. A schematic diagram showing the combination of WNT974 and ART increases ANAPC2, β-TrCP and GSK-3β expressions that lead to KRAS protein degradation via the ubiquitination ubiquitin–proteasome pathway. And then combination treatment inhibits CRC growth by suppressing PI3K/Akt/mTOR pathway
