Table 4:

Mediation of intervention effects on anxiety symptom reduction by antidepressant use among patients with at least moderate anxiety symptoms in a trial of a collaborative care model for treatment of depression and diabetes in India (n=172)

	RD	SE	p
Intervention → anti-depressant use
6 months	0.18	0.06	<0.001
12 months	0.20	0.05	<0.001
18 months	0.07	0.05	0.20
24 months	0.00	0.05	0.95
Anti-depressant use → anxiety symptom reduction	0.05	0.04	0.10
Average causal mediation effect	0.005	0.005	0.32
Direct effect	0.108	0.03	0.002
Total effect	0.113	0.03	<0.001
% Mediated	4.0%	5.5%	0.47

Abbreviations: RD, risk difference. SE, standard error.

Footnotes: Bold text indicates statistically significant estimate (p < 0.05).