Study | Reason for exclusion |
---|---|
Ambrosino 2008 | Part of a more complex intervention with 8 weeks pulmonary rehabilitation before 12 weeks of tiotropium versus placebo treatment |
Baloira 2005 | Less than 12 weeks study duration |
Bedard 2011 | Less than 12 weeks study duration |
Calverley 2000 | Less than 12 weeks study duration |
Casaburi 2005 | Part of a more complex intervention with 8 weeks pulmonary rehabilitation before 12 weeks of tiotropium versus placebo treatment |
Celli 2002 | Less than 12 weeks study duration |
da Fonseca 2010 | Part of a more complex intervention with an exercise programme |
de Guia 2004 | Tiotropium versus ipratropium, no placebo group, less than 12 weeks study duration |
Diba 2009 | Less than 12 weeks study duration |
Diba 2011 | Cross‐over study design |
Friedman 1998 | Less than 12 weeks study duration |
Fuhr 2010 | Cross‐over study design |
Gelb 2011 | Cross‐over study design |
Gurzhiy 2007 | Not an RCT as the study groups were moderate versus severe COPD, less than 12 weeks study duration |
Halpin 2006 | Systematic review of data |
Hasani 2001 | Less than 12 weeks study duration |
Hasani 2001b | Less than 12 weeks study duration |
Hirata 2003 | Tiotropium versus oxitropium, no placebo group |
Kerstjens 2004 | Tiotropium in combination with ipratropium or fenoterol or placebo, cross‐over study design |
Langley 2002 | Less than 12 weeks study duration |
McNicholas 2001 | Less than 12 weeks study duration |
Meshcheriakova 2007 | Tiotropium + ICS/LABA or tiotropium + ICS/LABA + threshold positive expiratory pressure (PEP) and inspiratory muscle trainer (IMT) devices (PID) training or tiotropium + ICS/LABA + physical training or ICS/LABA |
O'Donnell 2002 | Less than 12 weeks study duration |
O'Donnell 2004a | Less than 12 weeks study duration |
O'Donnell 2005 | Less than 12 weeks study duration |
O'Donnell 2005a | Cross‐over study design |
Olson 2009 | Less than 12 weeks study duration |
Reisner 2011 | Cross‐over study design |
Rossi 2008 | Cross‐over study design, less than 12 weeks study duration |
Schilling 2000 | Less than 12 weeks study duration |
Schurmann 2004 | Cross‐over study design, less than 12 weeks study duration |
Sposato 2005 | Less than 12 weeks study duration |
ten Hacken 2007 | Cross‐over study design |
van Noord 2006 | Cross‐over study design, less than 12 weeks study duration |
Vincken 2001 | Tiotropium versus ipratropium, no placebo group |
COPD: chronic obstructive pulmonary disease ICS: inhaled corticosteroids IMT: inspiratory muscle training LABA: long‐acting beta2‐agonist PEP: positive expiratory pressure