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. Author manuscript; available in PMC: 2022 Mar 20.
Published in final edited form as: Oncogene. 2021 Jul 8;40(32):5049–5065. doi: 10.1038/s41388-021-01868-5

Table 3:

Inhibitors of TGFβ signaling tested in various preclinical cancer models.

Target molecule Drug Name Preclinical Model Cancer Type Result
TGFβRI EW-7203 (Small molecule inhibitor) Chul-Yong et al., 2011 4T1 orthotopic-grafted mice Mammary cancer Inhibited lung metastasis.
TGFβRI EW-7197, IN-1130, EW-7195 (Small molecule inhibitor) Ji-Yeon et al., 2014, Chul-Yong 2014, Chul-Yong et al., 2011 (MMTV)/c-Neu mouse mammary tumor virus mice and 4T1 orthotopic-grafted mice Breast cancer Inhibited lung metastasis.