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. 2022 Feb 8;50(5):2651–2666. doi: 10.1093/nar/gkac073

Figure 2.

Figure 2.

Impact of codepletion of RAD51 with BRCA2 or 53BP1 on GC, SSA and EJ. (A) Silencing of RAD51 and BRCA2. (B) Impact of simultaneous depletion of RAD51 and BRCA2 on gene conversion (GC), SSA, and EJ. The values are shown normalized to the control siRNA (in black) and represent the average ± SEM of at least 5 independent experiments. (C–E) Impact of simultaneous depletion of RAD51 and 53BP1 on A-EJ measured with the EJ2 reporter (C), SSA (D) and gene conversion (E). The values are shown normalized to the control siRNA (in black) and represent the average ± SEM of at least three independent experiments. (*P< 0.05, **P< 0.01, ***P < 0.001, ****P< 0.0001, t-test compared to ‘siCT’).