Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 8;50(5):2651–2666. doi: 10.1093/nar/gkac073

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 6. — The roles of RAD51 in the selection of the DSB repair pathway. (1) C-NHEJ favored by 53BP1 and Ku80/70 competes with resection on DSBs. (2) After resection, BRCA2 loads RAD51 onto ssDNA in an ATP-dependent manner. The occupancy of ssDNA by RAD51 triggers gene conversion (in a catalytic manner) and suppresses the annealing step (independently of GC promotion), which could be RAD52-dependent, of nonconservative SSA and A-EJ. The blockage of annealing by RAD51 does not require strand exchange activity.