Table 1.
Parameter | Sham |
PAB |
||||
---|---|---|---|---|---|---|
Intact Male | Intact Female | OVX Female | Intact Male | Intact Female | OVX Female | |
Tibia length, mm | 44.3 ± 0.9 | 47.0 ± 1.1 | 43.0 ± 0.8 | 45.4 ± 1.2 | ||
Initial body weight, g | 267.38 ± 6.46 | 187.78 ± 4.62† | 254.00 ± 7.94‡ | 262.60 ± 2.35 | 181.89 ± 4.78† | 239.25 ± 8.85†‡ |
Terminal body weight, g | 469 ± 21 | 272 ± 8† | 366 ± 14†‡ | 455 ± 8 | 268 ± 8† | 346 ± 9†‡ |
Body weight gain, % | 75 ± 6 | 45 ± 3† | 44 ± 3† | 73 ± 3 | 48 ± 2† | 45 ± 2† |
Serum 17-β estradiol, pg/mL | 5.27 ± 0.66 | 14.11 ± 6.58 | 2.92 ± 0.33 | 5.82 ± 0.72 | 7.45 ± 2.13 | 2.66 ± 0.28 |
Values are presented as means ± SE. PAB, pulmonary artery banding; Sham, sham surgery. n = 8–10 animals per group. P < 0.05 for †female [intact or ovariectomized (OVX)] vs. male and ‡OVX vs. intact female (2-way ANOVA with Tukey’s honestly significant difference multiple comparison correction).