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Mitochondrial proteomics further reveals acute exercise increases several key mitophagy regulating proteins. Ingenuity pathway analysis (IPA) (n = 5/group) reveals changes in mitophagy protein abundance to predict activation or inhibition of the mitophagy pathway (A). Log-fold changes for specific mitophagy proteins were compared between sedentary (SED), treadmill running (EX), saline (SAL), and leupeptin (LEU) treatment groups (B). *P < 0.05 when comparing EX to SED condition.
