Figure 2.

Development of proteinuria and segmental glomerular sclerosis in podocyte-specific transcriptional coactivator with PDZ-binding motif (Taz) knockout (Taz^podKO) mice. A: representative Coomassie blue staining of 1 μL urine from Taz^podKO or Taz^podWT mice at 4 wk of age. B: proteinuria indicated by increases in the albumin-to-creatinine ratio in Taz^podKO mice. Values are means ± SE; n = 7. C: glomerular sclerosis was detected in Taz^podKO mice at 9 wk of age. Original magnification: ×400. WT, wild type.