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. 2022 Jan 10;102(3):1211–1261. doi: 10.1152/physrev.00024.2021

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Licensed under Creative Commons Attribution CC-BY 4.0. Published by the American Physiological Society.

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FIGURE 4. — Phylogenetic tree of junctophilin (JPH) isoforms. The phylogenetic tree was created using 57 JPH isoforms from 22 different species that were selected with different times of the last common ancestor. Protein sequences were aligned using MUSCLE in Mega-X using default settings, a distance matrix was generated, and the phylogenetic tree was generated using the neighbor joining method. Clades containing each of the isoforms are indicated. The scale bar represents the length of each branch as the average number of amino acid substitutions per site (per Mega-X).