FIGURE 6.

Evolutionary conservation of the junctophilin-2 (JHP2) membrane occupation and recognition nexus (MORN)-1 domain. Homologues of the Homo sapiens JPH2 protein were obtained using protein BLAST (see accession numbers). The selected top hit from each species with different evolutionary distances from humans were aligned using the MUSCLE feature in Mega-X. A distance matrix of the aligned sequences was generated using default settings. Estimated evolutionary distance was obtained from TimeTree (30). The colors represent the amino acid types; mya, millions of years ago.