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. 2021 Dec 20;102(3):1159–1210. doi: 10.1152/physrev.00022.2021

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FIGURE 6. — Functional coupling of transient receptor potential (TRP) channels with other ion channels. A: functional coupling between TRPV1 and KCNQ2 modulates neuronal excitability. PIP₂, phosphatidylinositol 4,5-bisphosphatase. B: clustering of TRPV1 and Ca_V1.2 channels regulates TRPV1 desensitization in neurons. C: a tripartite clustering of TRPV1, inositol trisphosphate (IP₃) receptor (IP₃R), and ANO1 controls membrane depolarization and dorsal root ganglion (DRG) excitability. PLC, phospholipase C. D: mucolytic TRP (TRPML)1s located in immobile lysosomes near ryanodine receptor (RyR) channels control large-conductance (BK) channel activity to regulate vascular smooth muscle contractility. P_o, open probability. STOCs, spontaneous transient outward currents. Figure created with Biorender.com.