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. 2021 Nov 19;43(12):1251–1264. doi: 10.1093/eurheartj/ehab772

Figure 1.

Figure 1

Functional and transcriptomic characteristics of murine hearts after exercise. (A) Echocardiographic parameters in 21 control mice undergoing 6 weeks of endurance treadmill training. FS, left ventricular fractional shortening; LVAW, left ventricular anterior wall; LVEF, left ventricular ejection fraction; LVPW, left ventricular posterior wall. Student’s t-test to compare baseline (−21) to effect of PKP2cKO 21 dpi. (B) Transcriptome of hearts from trained mice (6-week treadmill running protocol; n = 3) compared with that of sedentary controls (n = 6). Volcano plot of up-regulated (green) or down-regulated (blue) transcripts. The terms ‘up-regulated’ or ‘down-regulated’ refer to more or less abundance, respectively, of a given transcript in the hearts of mice that followed the training protocol, vs. the sedentary controls. Inclusion criteria: | Log2FC | > 0.5 and false discovery rate < 0.05. Dots in grey: transcripts excluded by criteria. The position of transcripts for desmosomal proteins plakophilin-2 (PKP2), desmocollin-2 (DSC2), and desmoglein-2 (DSG-2) together with additional genes of interest are noted with red and with purple dots. (C and D) KEGG (Kyoto Encyclopedia Genes and Genomes)-based identification of down-regulated and up-regulated pathways, respectively, in the differential transcriptome of trained control murine hearts.