Figure 3.
Echocardiographic changes in trained PKP2cKO mice compared with sedentary PKP2cKO mice. (A and B) Left ventricular ejection fraction (LVEF) and fractional shortening changes in 3-week trained PKP2-cKO compared with PKP2-cKO sedentary mice. (C and D) Left ventricular ejection fraction and fractional shortening changes between trained (i.e. animals completed 6 weeks of treadmill running) and sedentary PKP2-cKO mice. Purple: sedentary (n = 11 at 0 dpi, 14 at 14 and 21 dpi). Pink: 3-week training (n = 9). Red: trained mice (n = 15). DPI: days post-TAM injection. ‘0’ in C and D reflects the baseline pre-exercise in trained mice (3 weeks before TAM injection). Sedentary data in A and B also displayed in C and D to facilitate comparison. Top bars indicate P-values by unpaired Student’s t-test.